Musim 2021-22 La Liga Spanyol adalah musim ke-91 dari La Liga Spanyol, liga paling teratas di persepakbolaan profesional di Spanyol sejak dibentuk. Musim ini dimulai pada 13 Agustus 2021 sampai Mei 2022.
Atlético Madrid adalah juara bertahan. Dua puluh tim akan bersaing di La Liga, tujuh belas dari tim musim sebelumnya, serta tiga tim yang dipromosikan dari Segunda División.
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 14 Agu 2021, 02:00 | Valencia  | 1 – 0 |  Getafe |
| Sabtu, 14 Agu 2021, 22:00 | Osasuna  | 0 – 0 |  Espanyol |
| Minggu, 15 Agu 2021, 00:30 | Cádiz  | 1 – 1 |  Levante |
| Minggu, 15 Agu 2021, 00:30 | Mallorca  | 1 – 1 |  Real Betis |
| Minggu, 15 Agu 2021, 03:00 | Alavés  | 1 – 4 |  Real Madrid |
| Minggu, 15 Agu 2021, 22:30 | Celta Vigo  | 1 – 2 |  Atlético Madrid |
| Senin, 16 Agu 2021, 01:00 | Barcelona  | 4 – 2 |  Real Sociedad |
| Senin, 16 Agu 2021, 03:15 | Sevilla  | 3 – 0 |  Rayo Vallecano |
| Selasa, 17 Agu 2021, 01:00 | Villarreal  | 0 – 0 |  Granada |
| Selasa, 17 Agu 2021, 03:00 | Elche  | 0 – 0 |  Athletic Bilbao |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 21 Agu 2021, 02:00 | Real Betis | 1 – 1 | Cádiz |
| Sabtu, 21 Agu 2021, 22:00 | Alavés | 0 – 1 | Mallorca |
| Minggu, 22 Agu 2021, 00:30 | Espanyol | 0 – 0 | Villarreal |
| Minggu, 22 Agu 2021, 00:30 | Granada | 1 – 1 | Valencia |
| Minggu, 22 Agu 2021, 03:00 | Athletic Bilbao | 1 – 1 | Barcelona |
| Minggu, 22 Agu 2021, 22:00 | Real Sociedad | 1 – 0 | Rayo Vallecano |
| Senin, 23 Agu 2021, 00:30 | Atlético Madrid | 1 – 0 | Elche |
| Senin, 23 Agu 2021, 03:00 | Levante | 3 – 3 | Real Madrid |
| Selasa, 24 Agu 2021, 01:00 | Getafe | 0 – 1 | Sevilla |
| Selasa, 24 Agu 2021, 03:00 | Osasuna | 0 – 0 | Celta Vigo |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 28 Agu 2021, 01:00 | Mallorca | 1 – 0 | Espanyol |
| Sabtu, 28 Agu 2021, 03:15 | Valencia | 3 – 0 | Alavés |
| Sabtu, 28 Agu 2021, 22:00 | Celta Vigo | 0 – 1 | Athletic Bilbao |
| Minggu, 29 Agu 2021, 00:30 | Elche | 1 – 1 | Sevilla |
| Minggu, 29 Agu 2021, 00:30 | Real Sociedad | 1 – 0 | Levante |
| Minggu, 29 Agu 2021, 03:00 | Real Betis | 0 – 1 | Real Madrid |
| Minggu, 29 Agu 2021, 22:00 | Barcelona | 2 – 1 | Getafe |
| Senin, 30 Agu 2021, 00:30 | Cádiz | 2 – 3 | Osasuna |
| Senin, 30 Agu 2021, 00:30 | Rayo Vallecano | 4 – 0 | Granada |
| Senin, 30 Agu 2021, 03:00 | Atlético Madrid | 2 – 2 | Villarreal |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 11 Sep 2021, 02:00 | Levante | 1 – 1 | Rayo Vallecano |
| Sabtu, 11 Sep 2021, 19:00 | Espanyol | 1 – 2 | Atlético Madrid |
| Sabtu, 11 Sep 2021, 21:15 | Real Madrid | 5 – 2 | Celta Vigo |
| Minggu, 12 Sep 2021, 19:00 | Cádiz | 0 – 2 | Real Sociedad |
| Minggu, 12 Sep 2021, 21:15 | Osasuna | 1 – 4 | Valencia |
| Minggu, 12 Sep 2021, 23:30 | Getafe | 0 – 1 | Elche |
| Senin, 13 Sep 2021, 02:00 | Granada | 1 – 2 | Real Betis |
| Selasa, 14 Sep 2021, 02:00 | Athletic Bilbao | 2 – 0 | Mallorca |
| Rabu, 22 Des 2021, 01:00 | Villarreal | 5 – 2 | Alavés |
| Rabu, 22 Des 2021, 03:30 | Sevilla | 1 – 1 | Barcelona |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 18 Sep 2021, 02:00 | Celta Vigo | 1 – 2 | Cádiz |
| Sabtu, 18 Sep 2021, 19:00 | Rayo Vallecano | 3 – 0 | Getafe |
| Sabtu, 18 Sep 2021, 21:15 | Atlético Madrid | 0 – 0 | Athletic Bilbao |
| Sabtu, 18 Sep 2021, 23:30 | Elche | 1 – 1 | Levante |
| Minggu, 19 Sep 2021, 02:00 | Alavés | 0 – 2 | Osasuna |
| Minggu, 19 Sep 2021, 19:00 | Mallorca | 0 – 0 | Villarreal |
| Minggu, 19 Sep 2021, 21:15 | Real Sociedad | 0 – 0 | Sevilla |
| Minggu, 19 Sep 2021, 23:30 | Real Betis | 2 – 2 | Espanyol |
| Senin, 20 Sep 2021, 02:00 | Valencia | 1 – 2 | Real Madrid |
| Selasa, 21 Sep 2021, 02:00 | Barcelona | 1 – 1 | Granada |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Rabu, 22 Sep 2021, 00:30 | Getafe | 1 – 2 | Atlético Madrid |
| Rabu, 22 Sep 2021, 03:00 | Athletic Bilbao | 1 – 2 | Rayo Vallecano |
| Rabu, 22 Sep 2021, 03:00 | Levante | 0 – 2 | Celta Vigo |
| Kamis, 23 Sep 2021, 00:30 | Espanyol | 1 – 0 | Alavés |
| Kamis, 23 Sep 2021, 00:30 | Sevilla | 3 – 1 | Valencia |
| Kamis, 23 Sep 2021, 03:00 | Real Madrid | 6 – 1 | Mallorca |
| Kamis, 23 Sep 2021, 03:00 | Villarreal | 4 – 1 | Elche |
| Jumat, 24 Sep 2021, 00:30 | Granada | 2 – 3 | Real Sociedad |
| Jumat, 24 Sep 2021, 00:30 | Osasuna | 1 – 3 | Real Betis |
| Jumat, 24 Sep 2021, 03:00 | Cádiz | 0 – 0 | Barcelona |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 25 Sep 2021, 19:00 | Alavés | 1 – 0 | Atlético Madrid |
| Sabtu, 25 Sep 2021, 21:15 | Valencia | 1 – 1 | Athletic Bilbao |
| Sabtu, 25 Sep 2021, 23:30 | Sevilla | 2 – 0 | Espanyol |
| Minggu, 26 Sep 2021, 02:00 | Real Madrid | 0 – 0 | Villarreal |
| Minggu, 26 Sep 2021, 19:00 | Mallorca | 2 – 3 | Osasuna |
| Minggu, 26 Sep 2021, 21:15 | Barcelona | 3 – 0 | Levante |
| Minggu, 26 Sep 2021, 23:30 | Rayo Vallecano | 3 – 1 | Cádiz |
| Minggu, 26 Sep 2021, 23:30 | Real Sociedad | 1 – 0 | Elche |
| Senin, 27 Sep 2021, 02:00 | Real Betis | 2 – 0 | Getafe |
| Selasa, 28 Sep 2021, 02:00 | Celta Vigo | 1 – 0 | Granada |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 2 Okt 2021, 02:00 | Athletic Bilbao | 1 – 0 | Alavés |
| Sabtu, 2 Okt 2021, 19:00 | Osasuna | 1 – 0 | Rayo Vallecano |
| Sabtu, 2 Okt 2021, 21:15 | Mallorca | 1 – 0 | Levante |
| Sabtu, 2 Okt 2021, 23:30 | Cádiz | 0 – 0 | Valencia |
| Minggu, 3 Okt 2021, 02:00 | Atlético Madrid | 2 – 0 | Barcelona |
| Minggu, 3 Okt 2021, 19:00 | Elche | 1 – 0 | Celta Vigo |
| Minggu, 3 Okt 2021, 21:15 | Espanyol | 2 – 1 | Real Madrid |
| Minggu, 3 Okt 2021, 23:30 | Getafe | 1 – 1 | Real Sociedad |
| Minggu, 3 Okt 2021, 23:30 | Villarreal | 2 – 0 | Real Betis |
| Senin, 4 Okt 2021, 02:00 | Granada | 1 – 0 | Sevilla |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Minggu, 17 Okt 2021, 02:00 | Real Sociedad | 1 – 0 | Mallorca |
| Minggu, 17 Okt 2021, 19:00 | Rayo Vallecano | 2 – 1 | Elche |
| Minggu, 17 Okt 2021, 21:15 | Celta Vigo | 0 – 1 | Sevilla |
| Minggu, 17 Okt 2021, 23:30 | Levante | 0 – 0 | Getafe |
| Minggu, 17 Okt 2021, 23:30 | Villarreal | 1 – 2 | Osasuna |
| Senin, 18 Okt 2021, 02:00 | Barcelona | 3 – 1 | Valencia |
| Selasa, 19 Okt 2021, 00:00 | Alavés | 0 – 1 | Real Betis |
| Selasa, 19 Okt 2021, 02:00 | Espanyol | 2 – 0 | Cádiz |
| Kamis, 2 Des 2021, 03:00 | Real Madrid | 1 – 0 | Athletic Bilbao |
| Kamis, 23 Des 2021, 01:00 | Granada | 2 – 1 | Atlético Madrid |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 23 Okt 2021, 02:00 | Osasuna | 1 – 1 | Granada |
| Sabtu, 23 Okt 2021, 19:00 | Valencia | 2 – 2 | Mallorca |
| Sabtu, 23 Okt 2021, 21:15 | Cádiz | 0 – 2 | Alavés |
| Sabtu, 23 Okt 2021, 23:30 | Sevilla | 5 – 3 | Levante |
| Minggu, 24 Okt 2021, 02:00 | Athletic Bilbao | 2 – 1 | Villarreal |
| Minggu, 24 Okt 2021, 19:00 | Elche | 2 – 2 | Espanyol |
| Minggu, 24 Okt 2021, 21:15 | Barcelona | 1 – 2 | Real Madrid |
| Minggu, 24 Okt 2021, 23:30 | Real Betis | 3 – 2 | Rayo Vallecano |
| Senin, 25 Okt 2021, 02:00 | Atlético Madrid | 2 – 2 | Real Sociedad |
| Selasa, 26 Okt 2021, 02:00 | Getafe | 0 – 3 | Celta Vigo |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Rabu, 27 Okt 2021, 00:00 | Alavés | 1 – 0 | Elche |
| Rabu, 27 Okt 2021, 02:00 | Espanyol | 1 – 1 | Athletic Bilbao |
| Rabu, 27 Okt 2021, 02:30 | Villarreal | 3 – 3 | Cádiz |
| Kamis, 28 Okt 2021, 00:00 | Mallorca | 1 – 1 | Sevilla |
| Kamis, 28 Okt 2021, 00:00 | Rayo Vallecano | 1 – 0 | Barcelona |
| Kamis, 28 Okt 2021, 01:00 | Real Betis | 4 – 1 | Valencia |
| Kamis, 28 Okt 2021, 02:30 | Real Madrid | 0 – 0 | Osasuna |
| Jumat, 29 Okt 2021, 00:00 | Celta Vigo | 0 – 2 | Real Sociedad |
| Jumat, 29 Okt 2021, 01:00 | Granada | 1 – 1 | Getafe |
| Jumat, 29 Okt 2021, 02:30 | Levante | 2 – 2 | Atlético Madrid |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 30 Okt 2021, 19:00 | Elche | 1 – 2 | Real Madrid |
| Sabtu, 30 Okt 2021, 21:15 | Sevilla | 2 – 0 | Osasuna |
| Sabtu, 30 Okt 2021, 23:30 | Valencia | 2 – 0 | Villarreal |
| Minggu, 31 Okt 2021, 02:00 | Barcelona | 1 – 1 | Alavés |
| Minggu, 31 Okt 2021, 20:00 | Cádiz | 1 – 1 | Mallorca |
| Minggu, 31 Okt 2021, 22:15 | Atlético Madrid | 3 – 0 | Real Betis |
| Senin, 1 Nov 2021, 00:30 | Getafe | 2 – 1 | Espanyol |
| Senin, 1 Nov 2021, 03:00 | Real Sociedad | 1 – 1 | Athletic Bilbao |
| Selasa, 2 Nov 2021, 00:30 | Rayo Vallecano | 0 – 0 | Celta Vigo |
| Selasa, 2 Nov 2021, 03:00 | Levante | 0 – 3 | Granada |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 6 Nov 2021, 03:00 | Athletic Bilbao | 0 – 1 | Cádiz |
| Sabtu, 6 Nov 2021, 20:00 | Espanyol | 2 – 0 | Granada |
| Sabtu, 6 Nov 2021, 22:15 | Celta Vigo | 3 – 3 | Barcelona |
| Minggu, 7 Nov 2021, 00:30 | Alavés | 2 – 1 | Levante |
| Minggu, 7 Nov 2021, 03:00 | Real Madrid | 2 – 1 | Rayo Vallecano |
| Minggu, 7 Nov 2021, 20:00 | Villarreal | 1 – 0 | Getafe |
| Minggu, 7 Nov 2021, 22:15 | Valencia | 3 – 3 | Atlético Madrid |
| Senin, 8 Nov 2021, 00:30 | Mallorca | 2 – 2 | Elche |
| Senin, 8 Nov 2021, 00:30 | Osasuna | 0 – 2 | Real Sociedad |
| Senin, 8 Nov 2021, 03:00 | Real Betis | 0 – 2 | Sevilla |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 20 Nov 2021, 03:00 | Levante | 0 – 0 | Athletic Bilbao |
| Sabtu, 20 Nov 2021, 20:00 | Celta Vigo | 1 – 1 | Villarreal |
| Sabtu, 20 Nov 2021, 22:15 | Sevilla | 2 – 2 | Alavés |
| Minggu, 21 Nov 2021, 00:30 | Atlético Madrid | 1 – 0 | Osasuna |
| Minggu, 21 Nov 2021, 03:00 | Barcelona | 1 – 0 | Espanyol |
| Minggu, 21 Nov 2021, 20:00 | Getafe | 4 – 0 | Cádiz |
| Minggu, 21 Nov 2021, 22:15 | Granada | 1 – 4 | Real Madrid |
| Senin, 22 Nov 2021, 00:30 | Elche | 0 – 3 | Real Betis |
| Senin, 22 Nov 2021, 03:00 | Real Sociedad | 0 – 0 | Valencia |
| Selasa, 23 Nov 2021, 03:00 | Rayo Vallecano | 3 – 1 | Mallorca |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 27 Nov 2021, 03:00 | Athletic Bilbao | 2 – 2 | Granada |
| Sabtu, 27 Nov 2021, 20:00 | Alavés | 1 – 2 | Celta Vigo |
| Sabtu, 27 Nov 2021, 22:15 | Valencia | 1 – 1 | Rayo Vallecano |
| Minggu, 28 Nov 2021, 00:30 | Mallorca | 0 – 0 | Getafe |
| Minggu, 28 Nov 2021, 03:00 | Villarreal | 1 – 3 | Barcelona |
| Minggu, 28 Nov 2021, 20:00 | Real Betis | 3 – 1 | Levante |
| Minggu, 28 Nov 2021, 22:15 | Espanyol | 1 – 0 | Real Sociedad |
| Senin, 29 Nov 2021, 00:30 | Cádiz | 1 – 4 | Atlético Madrid |
| Senin, 29 Nov 2021, 03:00 | Real Madrid | 2 – 1 | Sevilla |
| Selasa, 30 Nov 2021, 03:00 | Osasuna | 1 – 1 | Elche |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 4 Des 2021, 03:00 | Granada | 2 – 1 | Alavés |
| Sabtu, 4 Des 2021, 20:00 | Atlético Madrid | 1 – 2 | Mallorca |
| Sabtu, 4 Des 2021, 20:00 | Sevilla | 1 – 0 | Villarreal |
| Sabtu, 4 Des 2021, 22:15 | Barcelona | 0 – 1 | Real Betis |
| Minggu, 5 Des 2021, 03:00 | Real Sociedad | 0 – 2 | Real Madrid |
| Minggu, 5 Des 2021, 20:00 | Rayo Vallecano | 1 – 0 | Espanyol |
| Minggu, 5 Des 2021, 22:15 | Elche | 3 – 1 | Cádiz |
| Senin, 6 Des 2021, 00:30 | Levante | 0 – 0 | Osasuna |
| Senin, 6 Des 2021, 03:00 | Celta Vigo | 1 – 2 | Valencia |
| Selasa, 7 Des 2021, 03:00 | Getafe | 0 – 0 | Athletic Bilbao |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 11 Des 2021, 03:00 | Mallorca | 0 – 0 | Celta Vigo |
| Sabtu, 11 Des 2021, 20:00 | Espanyol | 4 – 3 | Levante |
| Sabtu, 11 Des 2021, 22:15 | Alavés | 1 – 1 | Getafe |
| Minggu, 12 Des 2021, 00:30 | Valencia | 2 – 1 | Elche |
| Minggu, 12 Des 2021, 03:00 | Athletic Bilbao | 0 – 1 | Sevilla |
| Minggu, 12 Des 2021, 20:00 | Villarreal | 2 – 0 | Rayo Vallecano |
| Minggu, 12 Des 2021, 22:15 | Osasuna | 2 – 2 | Barcelona |
| Senin, 13 Des 2021, 00:30 | Real Betis | 4 – 0 | Real Sociedad |
| Senin, 13 Des 2021, 03:00 | Real Madrid | 2 – 0 | Atlético Madrid |
| Selasa, 14 Des 2021, 03:00 | Cádiz | 1 – 1 | Granada |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 18 Des 2021, 03:00 | Celta Vigo | 3 – 1 | Espanyol |
| Sabtu, 18 Des 2021, 20:00 | Rayo Vallecano | 2 – 0 | Alavés |
| Sabtu, 18 Des 2021, 22:15 | Real Sociedad | 1 – 3 | Villarreal |
| Minggu, 19 Des 2021, 00:30 | Barcelona | 3 – 2 | Elche |
| Minggu, 19 Des 2021, 03:00 | Sevilla | 2 – 1 | Atlético Madrid |
| Minggu, 19 Des 2021, 20:00 | Granada | 4 – 1 | Mallorca |
| Minggu, 19 Des 2021, 22:15 | Athletic Bilbao | 3 – 2 | Real Betis |
| Senin, 20 Des 2021, 00:30 | Getafe | 1 – 0 | Osasuna |
| Senin, 20 Des 2021, 03:00 | Real Madrid | 0 – 0 | Cádiz |
| Selasa, 21 Des 2021, 03:00 | Levante | 3 – 4 | Valencia |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Jumat, 31 Des 2021, 22:15 | Valencia | 1 – 2 | Espanyol |
| Minggu, 2 Jan 2022, 20:00 | Getafe | 1 – 0 | Real Madrid |
| Minggu, 2 Jan 2022, 22:15 | Atlético Madrid | 2 – 0 | Rayo Vallecano |
| Minggu, 2 Jan 2022, 22:15 | Elche | 0 – 0 | Granada |
| Senin, 3 Jan 2022, 00:30 | Alavés | 1 – 1 | Real Sociedad |
| Senin, 3 Jan 2022, 00:30 | Real Betis | 0 – 2 | Celta Vigo |
| Senin, 3 Jan 2022, 03:00 | Mallorca | 0 – 1 | Barcelona |
| Selasa, 4 Jan 2022, 01:00 | Villarreal | 5 – 0 | Levante |
| Selasa, 4 Jan 2022, 03:00 | Osasuna | 1 – 3 | Athletic Bilbao |
| Selasa, 4 Jan 2022, 03:15 | Cádiz | 0 – 1 | Sevilla |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 8 Jan 2022, 20:00 | Levante | 2 – 0 | Mallorca |
| Sabtu, 8 Jan 2022, 22:15 | Real Sociedad | 1 – 0 | Celta Vigo |
| Minggu, 9 Jan 2022, 00:30 | Granada | 1 – 1 | Barcelona |
| Minggu, 9 Jan 2022, 03:00 | Real Madrid | 4 – 1 | Valencia |
| Minggu, 9 Jan 2022, 20:00 | Rayo Vallecano | 1 – 1 | Real Betis |
| Minggu, 9 Jan 2022, 22:15 | Sevilla | 1 – 0 | Getafe |
| Senin, 10 Jan 2022, 00:30 | Alavés | 0 – 0 | Athletic Bilbao |
| Senin, 10 Jan 2022, 00:30 | Osasuna | 2 – 0 | Cádiz |
| Senin, 10 Jan 2022, 03:00 | Villarreal | 2 – 2 | Atlético Madrid |
| Selasa, 11 Jan 2022, 03:00 | Espanyol | 1 – 2 | Elche |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Kamis, 23 Des 2021, 03:30 | Athletic Bilbao | 1 – 2 | Real Madrid |
| Minggu, 16 Jan 2022, 20:00 | Elche | 1 – 0 | Villarreal |
| Rabu, 19 Jan 2022, 02:00 | Real Betis | 4 – 0 | Alavés |
| Rabu, 19 Jan 2022, 03:30 | Cádiz | 2 – 2 | Espanyol |
| Kamis, 20 Jan 2022, 01:00 | Celta Vigo | 2 – 0 | Osasuna |
| Kamis, 20 Jan 2022, 03:30 | Valencia | 1 – 1 | Sevilla |
| Jumat, 21 Jan 2022, 01:00 | Getafe | 4 – 2 | Granada |
| Kamis, 17 Feb 2022, 01:00 | Atlético Madrid | 0 – 1 | Levante |
| Kamis, 3 Mar 2022, 03:00 | Mallorca | 0 – 2 | Real Sociedad |
| Senin, 25 Apr 2022, 02:00 | Barcelona | 0 – 1 | Rayo Vallecano |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 22 Jan 2022, 03:00 | Espanyol | 1 – 4 | Real Betis |
| Sabtu, 22 Jan 2022, 20:00 | Levante | 0 – 2 | Cádiz |
| Sabtu, 22 Jan 2022, 22:15 | Granada | 0 – 2 | Osasuna |
| Minggu, 23 Jan 2022, 00:30 | Sevilla | 2 – 2 | Celta Vigo |
| Minggu, 23 Jan 2022, 03:00 | Atlético Madrid | 3 – 2 | Valencia |
| Minggu, 23 Jan 2022, 20:00 | Villarreal | 3 – 0 | Mallorca |
| Minggu, 23 Jan 2022, 22:15 | Real Madrid | 2 – 2 | Elche |
| Senin, 24 Jan 2022, 00:30 | Rayo Vallecano | 0 – 1 | Athletic Bilbao |
| Senin, 24 Jan 2022, 00:30 | Real Sociedad | 0 – 0 | Getafe |
| Senin, 24 Jan 2022, 03:00 | Alavés | 0 – 1 | Barcelona |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 5 Feb 2022, 03:00 | Getafe | 3 – 0 | Levante |
| Sabtu, 5 Feb 2022, 20:00 | Elche | 3 – 1 | Alavés |
| Sabtu, 5 Feb 2022, 22:15 | Mallorca | 2 – 1 | Cádiz |
| Minggu, 6 Feb 2022, 00:30 | Celta Vigo | 2 – 0 | Rayo Vallecano |
| Minggu, 6 Feb 2022, 03:00 | Osasuna | 0 – 0 | Sevilla |
| Minggu, 6 Feb 2022, 20:00 | Valencia | 0 – 0 | Real Sociedad |
| Minggu, 6 Feb 2022, 22:15 | Barcelona | 4 – 2 | Atlético Madrid |
| Senin, 7 Feb 2022, 00:30 | Real Betis | 0 – 2 | Villarreal |
| Senin, 7 Feb 2022, 03:00 | Real Madrid | 1 – 0 | Granada |
| Selasa, 8 Feb 2022, 03:00 | Athletic Bilbao | 2 – 1 | Espanyol |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 12 Feb 2022, 03:00 | Sevilla | 2 – 0 | Elche |
| Sabtu, 12 Feb 2022, 20:00 | Cádiz | 0 – 0 | Celta Vigo |
| Sabtu, 12 Feb 2022, 22:15 | Villarreal | 0 – 0 | Real Madrid |
| Minggu, 13 Feb 2022, 00:30 | Rayo Vallecano | 0 – 3 | Osasuna |
| Minggu, 13 Feb 2022, 03:00 | Atlético Madrid | 4 – 3 | Getafe |
| Minggu, 13 Feb 2022, 20:00 | Alavés | 2 – 1 | Valencia |
| Minggu, 13 Feb 2022, 22:15 | Levante | 2 – 4 | Real Betis |
| Senin, 14 Feb 2022, 00:30 | Real Sociedad | 2 – 0 | Granada |
| Senin, 14 Feb 2022, 03:00 | Espanyol | 2 – 2 | Barcelona |
| Selasa, 15 Feb 2022, 03:00 | Mallorca | 3 – 2 | Athletic Bilbao |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 19 Feb 2022, 03:00 | Elche | 2 – 1 | Rayo Vallecano |
| Sabtu, 19 Feb 2022, 20:00 | Granada | 1 – 4 | Villarreal |
| Sabtu, 19 Feb 2022, 22:15 | Osasuna | 0 – 3 | Atlético Madrid |
| Minggu, 20 Feb 2022, 00:30 | Cádiz | 1 – 1 | Getafe |
| Minggu, 20 Feb 2022, 03:00 | Real Madrid | 3 – 0 | Alavés |
| Minggu, 20 Feb 2022, 20:00 | Espanyol | 1 – 1 | Sevilla |
| Minggu, 20 Feb 2022, 22:15 | Valencia | 1 – 4 | Barcelona |
| Senin, 21 Feb 2022, 00:30 | Real Betis | 2 – 1 | Mallorca |
| Senin, 21 Feb 2022, 03:00 | Athletic Bilbao | 4 – 0 | Real Sociedad |
| Selasa, 22 Feb 2022, 03:00 | Celta Vigo | 1 – 1 | Levante |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 26 Feb 2022, 03:00 | Levante | 3 – 0 | Elche |
| Sabtu, 26 Feb 2022, 20:00 | Mallorca | 0 – 1 | Valencia |
| Sabtu, 26 Feb 2022, 22:15 | Getafe | 2 – 2 | Alavés |
| Minggu, 27 Feb 2022, 00:30 | Rayo Vallecano | 0 – 1 | Real Madrid |
| Minggu, 27 Feb 2022, 03:00 | Atlético Madrid | 2 – 0 | Celta Vigo |
| Minggu, 27 Feb 2022, 20:00 | Villarreal | 5 – 1 | Espanyol |
| Minggu, 27 Feb 2022, 22:15 | Sevilla | 2 – 1 | Real Betis |
| Senin, 28 Feb 2022, 00:30 | Real Sociedad | 1 – 0 | Osasuna |
| Senin, 28 Feb 2022, 03:00 | Barcelona | 4 – 0 | Athletic Bilbao |
| Selasa, 1 Mar 2022, 03:00 | Granada | 0 – 0 | Cádiz |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 5 Mar 2022, 03:00 | Alavés | 0 – 0 | Sevilla |
| Sabtu, 5 Mar 2022, 20:00 | Osasuna | 1 – 0 | Villarreal |
| Sabtu, 5 Mar 2022, 22:15 | Espanyol | 2 – 0 | Getafe |
| Minggu, 6 Mar 2022, 00:30 | Valencia | 3 – 1 | Granada |
| Minggu, 6 Mar 2022, 03:00 | Real Madrid | 4 – 1 | Real Sociedad |
| Minggu, 6 Mar 2022, 20:00 | Cádiz | 2 – 0 | Rayo Vallecano |
| Minggu, 6 Mar 2022, 22:15 | Elche | 1 – 2 | Barcelona |
| Senin, 7 Mar 2022, 00:30 | Celta Vigo | 4 – 3 | Mallorca |
| Senin, 7 Mar 2022, 03:00 | Real Betis | 1 – 3 | Atlético Madrid |
| Selasa, 8 Mar 2022, 03:00 | Athletic Bilbao | 3 – 1 | Levante |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 12 Mar 2022, 03:00 | Atlético Madrid | 2 – 1 | Cádiz |
| Sabtu, 12 Mar 2022, 20:00 | Levante | 1 – 1 | Espanyol |
| Sabtu, 12 Mar 2022, 22:15 | Granada | 0 – 1 | Elche |
| Minggu, 13 Mar 2022, 00:30 | Villarreal | 1 – 0 | Celta Vigo |
| Minggu, 13 Mar 2022, 03:00 | Getafe | 0 – 0 | Valencia |
| Minggu, 13 Mar 2022, 20:00 | Rayo Vallecano | 1 – 1 | Sevilla |
| Minggu, 13 Mar 2022, 22:15 | Real Betis | 1 – 0 | Athletic Bilbao |
| Senin, 14 Mar 2022, 00:30 | Real Sociedad | 1 – 0 | Alavés |
| Senin, 14 Mar 2022, 03:00 | Barcelona | 4 – 0 | Osasuna |
| Selasa, 15 Mar 2022, 03:00 | Mallorca | 0 – 3 | Real Madrid |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 19 Mar 2022, 03:00 | Athletic Bilbao | 1 – 1 | Getafe |
| Sabtu, 19 Mar 2022, 20:00 | Alavés | 2 – 3 | Granada |
| Sabtu, 19 Mar 2022, 22:15 | Elche | 0 – 1 | Valencia |
| Minggu, 20 Mar 2022, 00:30 | Osasuna | 3 – 1 | Levante |
| Minggu, 20 Mar 2022, 03:00 | Rayo Vallecano | 0 – 1 | Atlético Madrid |
| Minggu, 20 Mar 2022, 20:00 | Espanyol | 1 – 0 | Mallorca |
| Minggu, 20 Mar 2022, 22:15 | Cádiz | 1 – 0 | Villarreal |
| Minggu, 20 Mar 2022, 22:15 | Celta Vigo | 0 – 0 | Real Betis |
| Senin, 21 Mar 2022, 00:30 | Sevilla | 0 – 0 | Real Sociedad |
| Senin, 21 Mar 2022, 03:00 | Real Madrid | 0 – 4 | Barcelona |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 2 Apr 2022, 19:00 | Getafe | 1 – 0 | Mallorca |
| Sabtu, 2 Apr 2022, 21:15 | Levante | 2 – 0 | Villarreal |
| Sabtu, 2 Apr 2022, 23:30 | Celta Vigo | 1 – 2 | Real Madrid |
| Minggu, 3 Apr 2022, 02:00 | Atlético Madrid | 4 – 1 | Alavés |
| Minggu, 3 Apr 2022, 19:00 | Athletic Bilbao | 2 – 1 | Elche |
| Minggu, 3 Apr 2022, 21:15 | Real Betis | 4 – 1 | Osasuna |
| Minggu, 3 Apr 2022, 23:30 | Granada | 2 – 2 | Rayo Vallecano |
| Minggu, 3 Apr 2022, 23:30 | Valencia | 0 – 0 | Cádiz |
| Senin, 4 Apr 2022, 02:00 | Barcelona | 1 – 0 | Sevilla |
| Selasa, 5 Apr 2022, 02:00 | Real Sociedad | 1 – 0 | Espanyol |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 9 Apr 2022, 02:00 | Sevilla | 4 – 2 | Granada |
| Sabtu, 9 Apr 2022, 19:00 | Cádiz | 1 – 2 | Real Betis |
| Sabtu, 9 Apr 2022, 21:15 | Mallorca | 1 – 0 | Atlético Madrid |
| Sabtu, 9 Apr 2022, 23:30 | Villarreal | 1 – 1 | Athletic Bilbao |
| Minggu, 10 Apr 2022, 02:00 | Real Madrid | 2 – 0 | Getafe |
| Minggu, 10 Apr 2022, 19:00 | Osasuna | 1 – 0 | Alavés |
| Minggu, 10 Apr 2022, 21:15 | Espanyol | 1 – 0 | Celta Vigo |
| Minggu, 10 Apr 2022, 23:30 | Elche | 1 – 2 | Real Sociedad |
| Senin, 11 Apr 2022, 02:00 | Levante | 2 – 3 | Barcelona |
| Selasa, 12 Apr 2022, 02:00 | Rayo Vallecano | 1 – 1 | Valencia |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 16 Apr 2022, 02:00 | Real Sociedad | 0 – 0 | Real Betis |
| Sabtu, 16 Apr 2022, 19:00 | Elche | 3 – 0 | Mallorca |
| Sabtu, 16 Apr 2022, 21:15 | Alavés | 1 – 0 | Rayo Vallecano |
| Sabtu, 16 Apr 2022, 23:30 | Valencia | 1 – 2 | Osasuna |
| Minggu, 17 Apr 2022, 02:00 | Getafe | 1 – 2 | Villarreal |
| Minggu, 17 Apr 2022, 19:00 | Granada | 1 – 4 | Levante |
| Minggu, 17 Apr 2022, 21:15 | Atlético Madrid | 2 – 1 | Espanyol |
| Minggu, 17 Apr 2022, 23:30 | Athletic Bilbao | 0 – 2 | Celta Vigo |
| Senin, 18 Apr 2022, 02:00 | Sevilla | 2 – 3 | Real Madrid |
| Selasa, 19 Apr 2022, 02:00 | Barcelona | 0 – 1 | Cádiz |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Rabu, 20 Apr 2022, 00:00 | Mallorca | 2 – 1 | Alavés |
| Rabu, 20 Apr 2022, 02:00 | Real Betis | 0 – 1 | Elche |
| Rabu, 20 Apr 2022, 02:30 | Villarreal | 2 – 0 | Valencia |
| Kamis, 21 Apr 2022, 00:00 | Atlético Madrid | 0 – 0 | Granada |
| Kamis, 21 Apr 2022, 01:00 | Celta Vigo | 0 – 2 | Getafe |
| Kamis, 21 Apr 2022, 02:30 | Osasuna | 1 – 3 | Real Madrid |
| Jumat, 22 Apr 2022, 00:00 | Espanyol | 0 – 1 | Rayo Vallecano |
| Jumat, 22 Apr 2022, 00:00 | Levante | 2 – 3 | Sevilla |
| Jumat, 22 Apr 2022, 01:00 | Cádiz | 2 – 3 | Athletic Bilbao |
| Jumat, 22 Apr 2022, 02:30 | Real Sociedad | 0 – 1 | Barcelona |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 30 Apr 2022, 02:00 | Sevilla | 1 – 1 | Cádiz |
| Sabtu, 30 Apr 2022, 19:00 | Alavés | 2 – 1 | Villarreal |
| Sabtu, 30 Apr 2022, 21:15 | Real Madrid | 4 – 0 | Espanyol |
| Sabtu, 30 Apr 2022, 23:30 | Valencia | 1 – 1 | Levante |
| Minggu, 1 Mei 2022, 02:00 | Athletic Bilbao | 2 – 0 | Atlético Madrid |
| Minggu, 1 Mei 2022, 19:00 | Elche | 1 – 1 | Osasuna |
| Minggu, 1 Mei 2022, 21:15 | Granada | 1 – 1 | Celta Vigo |
| Minggu, 1 Mei 2022, 23:30 | Rayo Vallecano | 1 – 1 | Real Sociedad |
| Senin, 2 Mei 2022, 02:00 | Barcelona | 2 – 1 | Mallorca |
| Selasa, 3 Mei 2022, 02:00 | Getafe | 0 – 0 | Real Betis |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 7 Mei 2022, 02:00 | Levante | 2 – 1 | Real Sociedad |
| Sabtu, 7 Mei 2022, 19:00 | Mallorca | 2 – 6 | Granada |
| Sabtu, 7 Mei 2022, 21:15 | Athletic Bilbao | 0 – 0 | Valencia |
| Sabtu, 7 Mei 2022, 23:30 | Cádiz | 3 – 0 | Elche |
| Sabtu, 7 Mei 2022, 23:30 | Celta Vigo | 4 – 0 | Alavés |
| Minggu, 8 Mei 2022, 02:00 | Real Betis | 1 – 2 | Barcelona |
| Minggu, 8 Mei 2022, 19:00 | Getafe | 0 – 1 | Rayo Vallecano |
| Minggu, 8 Mei 2022, 21:15 | Villarreal | 1 – 1 | Sevilla |
| Minggu, 8 Mei 2022, 23:30 | Espanyol | 1 – 1 | Osasuna |
| Senin, 9 Mei 2022, 02:00 | Atlético Madrid | 1 – 0 | Real Madrid |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Rabu, 11 Mei 2022, 00:00 | Valencia | 0 – 3 | Real Betis |
| Rabu, 11 Mei 2022, 01:00 | Granada | 1 – 0 | Athletic Bilbao |
| Rabu, 11 Mei 2022, 02:30 | Barcelona | 3 – 1 | Celta Vigo |
| Kamis, 12 Mei 2022, 00:00 | Alavés | 2 – 1 | Espanyol |
| Kamis, 12 Mei 2022, 00:00 | Osasuna | 1 – 1 | Getafe |
| Kamis, 12 Mei 2022, 01:30 | Sevilla | 0 – 0 | Mallorca |
| Kamis, 12 Mei 2022, 02:30 | Elche | 0 – 2 | Atlético Madrid |
| Jumat, 13 Mei 2022, 00:00 | Real Sociedad | 3 – 0 | Cádiz |
| Jumat, 13 Mei 2022, 01:00 | Rayo Vallecano | 1 – 5 | Villarreal |
| Jumat, 13 Mei 2022, 02:30 | Real Madrid | 6 – 0 | Levante |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 14 Mei 2022, 23:30 | Espanyol | 1 – 1 | Valencia |
| Minggu, 15 Mei 2022, 02:00 | Celta Vigo | 1 – 0 | Elche |
| Senin, 16 Mei 2022, 00:30 | Athletic Bilbao | 2 – 0 | Osasuna |
| Senin, 16 Mei 2022, 00:30 | Atlético Madrid | 1 – 1 | Sevilla |
| Senin, 16 Mei 2022, 00:30 | Real Betis | 2 – 0 | Granada |
| Senin, 16 Mei 2022, 00:30 | Cádiz | 1 – 1 | Real Madrid |
| Senin, 16 Mei 2022, 00:30 | Getafe | 0 – 0 | Barcelona |
| Senin, 16 Mei 2022, 00:30 | Levante | 3 – 1 | Alavés |
| Senin, 16 Mei 2022, 00:30 | Mallorca | 2 – 1 | Rayo Vallecano |
| Senin, 16 Mei 2022, 00:30 | Villarreal | 1 – 2 | Real Sociedad |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Minggu, 22 Mei 2022, 23:30 | Alavés | 0 – 1 | Cádiz |
| Minggu, 22 Mei 2022, 23:30 | Barcelona | 0 – 2 | Villarreal |
| Minggu, 22 Mei 2022, 23:30 | Elche | 3 – 1 | Getafe |
| Minggu, 22 Mei 2022, 23:30 | Granada | 0 – 0 | Espanyol |
| Minggu, 22 Mei 2022, 23:30 | Osasuna | 0 – 2 | Mallorca |
| Minggu, 22 Mei 2022, 23:30 | Rayo Vallecano | 2 – 4 | Levante |
| Minggu, 22 Mei 2022, 23:30 | Real Madrid | 0 – 0 | Real Betis |
| Minggu, 22 Mei 2022, 23:30 | Real Sociedad | 1 – 2 | Atlético Madrid |
| Minggu, 22 Mei 2022, 23:30 | Sevilla | 1 – 0 | Athletic Bilbao |
| Minggu, 22 Mei 2022, 23:30 | Valencia | 2 – 0 | Celta Vigo |
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