Liga Serie A Italia musim 2021–22 menjadi musim ke-120 Liga papan atas sepakbola Italia, musim ke-90 dalam turnamen round-robin, dan yang ke-12 sejak organisasinya di bawah komite liga yang terpisah dari Serie B.
Inter Milan adalah juara bertahan. Musim ini berjalan mulai 22 Agustus 2021 hingga 23 Mei 2022.
Tim yang dipromosikan langsung dari Serie B 2020–21 adalah
Empoli dan
Salernitana, sementara tim terakhir yang bergabung adalah
Venezia yang memenangkan play-off promosi ke Serie A.
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 21 Agu 2021, 23:30 | Internazionale  | 4 – 0 |  Genoa |
| Sabtu, 21 Agu 2021, 23:30 | Hellas Verona  | 2 – 3 |  Sassuolo |
| Minggu, 22 Agu 2021, 01:45 | Empoli  | 1 – 3 |  Lazio |
| Minggu, 22 Agu 2021, 01:45 | Torino  | 1 – 2 |  Atalanta |
| Minggu, 22 Agu 2021, 23:30 | Bologna  | 3 – 2 |  Salernitana |
| Minggu, 22 Agu 2021, 23:30 | Udinese  | 2 – 2 |  Juventus |
| Senin, 23 Agu 2021, 01:45 | Roma  | 3 – 1 |  Fiorentina |
| Senin, 23 Agu 2021, 01:45 | Napoli  | 2 – 0 |  Venezia |
| Senin, 23 Agu 2021, 23:30 | Cagliari  | 2 – 2 |  Spezia |
| Selasa, 24 Agu 2021, 01:45 | Sampdoria  | 0 – 1 |  Milan |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Jumat, 27 Agu 2021, 23:30 | Udinese | 3 – 0 | Venezia |
| Sabtu, 28 Agu 2021, 01:45 | Hellas Verona | 1 – 3 | Internazionale |
| Sabtu, 28 Agu 2021, 23:30 | Atalanta | 0 – 0 | Bologna |
| Sabtu, 28 Agu 2021, 23:30 | Lazio | 6 – 1 | Spezia |
| Minggu, 29 Agu 2021, 01:45 | Fiorentina | 2 – 1 | Torino |
| Minggu, 29 Agu 2021, 01:45 | Juventus | 0 – 1 | Empoli |
| Minggu, 29 Agu 2021, 23:30 | Genoa | 1 – 2 | Napoli |
| Minggu, 29 Agu 2021, 23:30 | Sassuolo | 0 – 0 | Sampdoria |
| Senin, 30 Agu 2021, 01:45 | Milan | 4 – 1 | Cagliari |
| Senin, 30 Agu 2021, 01:45 | Salernitana | 0 – 4 | Roma |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 11 Sep 2021, 20:00 | Empoli | 1 – 2 | Venezia |
| Sabtu, 11 Sep 2021, 23:00 | Napoli | 2 – 1 | Juventus |
| Minggu, 12 Sep 2021, 01:45 | Atalanta | 1 – 2 | Fiorentina |
| Minggu, 12 Sep 2021, 17:30 | Sampdoria | 2 – 2 | Internazionale |
| Minggu, 12 Sep 2021, 20:00 | Cagliari | 2 – 3 | Genoa |
| Minggu, 12 Sep 2021, 20:00 | Spezia | 0 – 1 | Udinese |
| Minggu, 12 Sep 2021, 20:00 | Torino | 4 – 0 | Salernitana |
| Minggu, 12 Sep 2021, 23:00 | Milan | 2 – 0 | Lazio |
| Senin, 13 Sep 2021, 01:45 | Roma | 2 – 1 | Sassuolo |
| Selasa, 14 Sep 2021, 01:45 | Bologna | 1 – 0 | Hellas Verona |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 18 Sep 2021, 01:45 | Sassuolo | 0 – 1 | Torino |
| Sabtu, 18 Sep 2021, 20:00 | Genoa | 1 – 2 | Fiorentina |
| Sabtu, 18 Sep 2021, 23:00 | Internazionale | 6 – 1 | Bologna |
| Minggu, 19 Sep 2021, 01:45 | Salernitana | 0 – 1 | Atalanta |
| Minggu, 19 Sep 2021, 17:30 | Empoli | 0 – 3 | Sampdoria |
| Minggu, 19 Sep 2021, 20:00 | Venezia | 1 – 2 | Spezia |
| Minggu, 19 Sep 2021, 23:00 | Lazio | 2 – 2 | Cagliari |
| Minggu, 19 Sep 2021, 23:00 | Hellas Verona | 3 – 2 | Roma |
| Senin, 20 Sep 2021, 01:45 | Juventus | 1 – 1 | Milan |
| Selasa, 21 Sep 2021, 01:45 | Udinese | 0 – 4 | Napoli |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Selasa, 21 Sep 2021, 23:30 | Bologna | 2 – 2 | Genoa |
| Rabu, 22 Sep 2021, 01:45 | Atalanta | 2 – 1 | Sassuolo |
| Rabu, 22 Sep 2021, 01:45 | Fiorentina | 1 – 3 | Internazionale |
| Rabu, 22 Sep 2021, 23:30 | Salernitana | 2 – 2 | Hellas Verona |
| Rabu, 22 Sep 2021, 23:30 | Spezia | 2 – 3 | Juventus |
| Kamis, 23 Sep 2021, 01:45 | Milan | 2 – 0 | Venezia |
| Kamis, 23 Sep 2021, 01:45 | Cagliari | 0 – 2 | Empoli |
| Kamis, 23 Sep 2021, 23:30 | Sampdoria | 0 – 4 | Napoli |
| Kamis, 23 Sep 2021, 23:30 | Torino | 1 – 1 | Lazio |
| Jumat, 24 Sep 2021, 01:45 | Roma | 1 – 0 | Udinese |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 25 Sep 2021, 20:00 | Spezia | 1 – 2 | Milan |
| Sabtu, 25 Sep 2021, 23:00 | Internazionale | 2 – 2 | Atalanta |
| Minggu, 26 Sep 2021, 01:45 | Genoa | 3 – 3 | Hellas Verona |
| Minggu, 26 Sep 2021, 17:30 | Juventus | 3 – 2 | Sampdoria |
| Minggu, 26 Sep 2021, 20:00 | Empoli | 4 – 2 | Bologna |
| Minggu, 26 Sep 2021, 20:00 | Sassuolo | 1 – 0 | Salernitana |
| Minggu, 26 Sep 2021, 20:00 | Udinese | 0 – 1 | Fiorentina |
| Minggu, 26 Sep 2021, 23:00 | Lazio | 3 – 2 | Roma |
| Senin, 27 Sep 2021, 01:45 | Napoli | 2 – 0 | Cagliari |
| Selasa, 28 Sep 2021, 01:45 | Venezia | 1 – 1 | Torino |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 2 Okt 2021, 01:45 | Cagliari | 1 – 1 | Venezia |
| Sabtu, 2 Okt 2021, 20:00 | Salernitana | 1 – 0 | Genoa |
| Sabtu, 2 Okt 2021, 23:00 | Torino | 0 – 1 | Juventus |
| Minggu, 3 Okt 2021, 01:45 | Sassuolo | 1 – 2 | Internazionale |
| Minggu, 3 Okt 2021, 17:30 | Bologna | 3 – 0 | Lazio |
| Minggu, 3 Okt 2021, 20:00 | Sampdoria | 3 – 3 | Udinese |
| Minggu, 3 Okt 2021, 20:00 | Hellas Verona | 4 – 0 | Spezia |
| Minggu, 3 Okt 2021, 23:00 | Roma | 2 – 0 | Empoli |
| Minggu, 3 Okt 2021, 23:00 | Fiorentina | 1 – 2 | Napoli |
| Senin, 4 Okt 2021, 01:45 | Atalanta | 2 – 3 | Milan |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 16 Okt 2021, 20:00 | Spezia | 2 – 1 | Salernitana |
| Sabtu, 16 Okt 2021, 23:00 | Lazio | 3 – 1 | Internazionale |
| Minggu, 17 Okt 2021, 01:45 | Milan | 3 – 2 | Hellas Verona |
| Minggu, 17 Okt 2021, 17:30 | Cagliari | 3 – 1 | Sampdoria |
| Minggu, 17 Okt 2021, 20:00 | Empoli | 1 – 4 | Atalanta |
| Minggu, 17 Okt 2021, 20:00 | Genoa | 2 – 2 | Sassuolo |
| Minggu, 17 Okt 2021, 20:00 | Udinese | 1 – 1 | Bologna |
| Minggu, 17 Okt 2021, 23:00 | Napoli | 1 – 0 | Torino |
| Senin, 18 Okt 2021, 01:45 | Juventus | 1 – 0 | Roma |
| Selasa, 19 Okt 2021, 01:45 | Venezia | 1 – 0 | Fiorentina |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Jumat, 22 Okt 2021, 23:30 | Torino | 3 – 2 | Genoa |
| Sabtu, 23 Okt 2021, 01:45 | Sampdoria | 2 – 1 | Spezia |
| Sabtu, 23 Okt 2021, 20:00 | Salernitana | 2 – 4 | Empoli |
| Sabtu, 23 Okt 2021, 23:00 | Sassuolo | 3 – 1 | Venezia |
| Minggu, 24 Okt 2021, 01:45 | Bologna | 2 – 4 | Milan |
| Minggu, 24 Okt 2021, 17:30 | Atalanta | 1 – 1 | Udinese |
| Minggu, 24 Okt 2021, 20:00 | Fiorentina | 3 – 0 | Cagliari |
| Minggu, 24 Okt 2021, 20:00 | Hellas Verona | 4 – 1 | Lazio |
| Minggu, 24 Okt 2021, 23:00 | Roma | 0 – 0 | Napoli |
| Senin, 25 Okt 2021, 01:45 | Internazionale | 1 – 1 | Juventus |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Selasa, 26 Okt 2021, 23:30 | Spezia | 1 – 1 | Genoa |
| Selasa, 26 Okt 2021, 23:30 | Venezia | 1 – 2 | Salernitana |
| Rabu, 27 Okt 2021, 01:45 | Milan | 1 – 0 | Torino |
| Rabu, 27 Okt 2021, 23:30 | Juventus | 1 – 2 | Sassuolo |
| Rabu, 27 Okt 2021, 23:30 | Sampdoria | 1 – 3 | Atalanta |
| Rabu, 27 Okt 2021, 23:30 | Udinese | 1 – 1 | Hellas Verona |
| Kamis, 28 Okt 2021, 01:45 | Cagliari | 1 – 2 | Roma |
| Kamis, 28 Okt 2021, 01:45 | Empoli | 0 – 2 | Internazionale |
| Kamis, 28 Okt 2021, 01:45 | Lazio | 1 – 0 | Fiorentina |
| Jumat, 29 Okt 2021, 01:45 | Napoli | 3 – 0 | Bologna |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 30 Okt 2021, 20:00 | Atalanta | 2 – 2 | Lazio |
| Sabtu, 30 Okt 2021, 23:00 | Hellas Verona | 2 – 1 | Juventus |
| Minggu, 31 Okt 2021, 01:45 | Torino | 3 – 0 | Sampdoria |
| Minggu, 31 Okt 2021, 18:30 | Internazionale | 2 – 0 | Udinese |
| Minggu, 31 Okt 2021, 21:00 | Fiorentina | 3 – 0 | Spezia |
| Minggu, 31 Okt 2021, 21:00 | Genoa | 0 – 0 | Venezia |
| Minggu, 31 Okt 2021, 21:00 | Sassuolo | 1 – 2 | Empoli |
| Senin, 1 Nov 2021, 00:00 | Salernitana | 0 – 1 | Napoli |
| Senin, 1 Nov 2021, 02:45 | Roma | 1 – 2 | Milan |
| Selasa, 2 Nov 2021, 02:45 | Bologna | 2 – 0 | Cagliari |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 6 Nov 2021, 02:45 | Empoli | 2 – 2 | Genoa |
| Sabtu, 6 Nov 2021, 21:00 | Spezia | 1 – 0 | Torino |
| Minggu, 7 Nov 2021, 00:00 | Juventus | 1 – 0 | Fiorentina |
| Minggu, 7 Nov 2021, 02:45 | Cagliari | 1 – 2 | Atalanta |
| Minggu, 7 Nov 2021, 18:30 | Venezia | 3 – 2 | Roma |
| Minggu, 7 Nov 2021, 21:00 | Sampdoria | 1 – 2 | Bologna |
| Minggu, 7 Nov 2021, 21:00 | Udinese | 3 – 2 | Sassuolo |
| Senin, 8 Nov 2021, 00:00 | Lazio | 3 – 0 | Salernitana |
| Senin, 8 Nov 2021, 00:00 | Napoli | 1 – 1 | Hellas Verona |
| Senin, 8 Nov 2021, 02:45 | Milan | 1 – 1 | Internazionale |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 20 Nov 2021, 21:00 | Atalanta | 5 – 2 | Spezia |
| Minggu, 21 Nov 2021, 00:00 | Lazio | 0 – 2 | Juventus |
| Minggu, 21 Nov 2021, 02:45 | Fiorentina | 4 – 3 | Milan |
| Minggu, 21 Nov 2021, 18:30 | Sassuolo | 2 – 2 | Cagliari |
| Minggu, 21 Nov 2021, 21:00 | Bologna | 0 – 1 | Venezia |
| Minggu, 21 Nov 2021, 21:00 | Salernitana | 0 – 2 | Sampdoria |
| Senin, 22 Nov 2021, 00:00 | Internazionale | 3 – 2 | Napoli |
| Senin, 22 Nov 2021, 02:45 | Genoa | 0 – 2 | Roma |
| Selasa, 23 Nov 2021, 00:30 | Hellas Verona | 2 – 1 | Empoli |
| Selasa, 23 Nov 2021, 02:45 | Torino | 2 – 1 | Udinese |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 27 Nov 2021, 02:45 | Cagliari | 1 – 1 | Salernitana |
| Sabtu, 27 Nov 2021, 02:45 | Empoli | 2 – 1 | Fiorentina |
| Sabtu, 27 Nov 2021, 21:00 | Sampdoria | 3 – 1 | Hellas Verona |
| Minggu, 28 Nov 2021, 00:00 | Juventus | 0 – 1 | Atalanta |
| Minggu, 28 Nov 2021, 02:45 | Venezia | 0 – 2 | Internazionale |
| Minggu, 28 Nov 2021, 18:30 | Udinese | 0 – 0 | Genoa |
| Minggu, 28 Nov 2021, 21:00 | Milan | 1 – 3 | Sassuolo |
| Minggu, 28 Nov 2021, 21:00 | Spezia | 0 – 1 | Bologna |
| Senin, 29 Nov 2021, 00:00 | Roma | 1 – 0 | Torino |
| Senin, 29 Nov 2021, 02:45 | Napoli | 4 – 0 | Lazio |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Rabu, 1 Des 2021, 00:30 | Atalanta | 4 – 0 | Venezia |
| Rabu, 1 Des 2021, 00:30 | Fiorentina | 3 – 1 | Sampdoria |
| Rabu, 1 Des 2021, 02:45 | Salernitana | 0 – 2 | Juventus |
| Rabu, 1 Des 2021, 02:45 | Hellas Verona | 0 – 0 | Cagliari |
| Kamis, 2 Des 2021, 00:30 | Bologna | 1 – 0 | Roma |
| Kamis, 2 Des 2021, 00:30 | Internazionale | 2 – 0 | Spezia |
| Kamis, 2 Des 2021, 02:45 | Genoa | 0 – 3 | Milan |
| Kamis, 2 Des 2021, 02:45 | Sassuolo | 2 – 2 | Napoli |
| Jumat, 3 Des 2021, 00:30 | Torino | 2 – 2 | Empoli |
| Jumat, 3 Des 2021, 02:45 | Lazio | 4 – 4 | Udinese |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 4 Des 2021, 21:00 | Milan | 2 – 0 | Salernitana |
| Minggu, 5 Des 2021, 00:00 | Roma | 0 – 3 | Internazionale |
| Minggu, 5 Des 2021, 02:45 | Napoli | 2 – 3 | Atalanta |
| Minggu, 5 Des 2021, 18:30 | Bologna | 2 – 3 | Fiorentina |
| Minggu, 5 Des 2021, 21:00 | Spezia | 2 – 2 | Sassuolo |
| Minggu, 5 Des 2021, 21:00 | Venezia | 3 – 4 | Hellas Verona |
| Senin, 6 Des 2021, 00:00 | Sampdoria | 1 – 3 | Lazio |
| Senin, 6 Des 2021, 02:45 | Juventus | 2 – 0 | Genoa |
| Selasa, 7 Des 2021, 00:30 | Empoli | 3 – 1 | Udinese |
| Selasa, 7 Des 2021, 02:45 | Cagliari | 1 – 1 | Torino |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 11 Des 2021, 02:45 | Genoa | 1 – 3 | Sampdoria |
| Sabtu, 11 Des 2021, 21:00 | Fiorentina | 4 – 0 | Salernitana |
| Minggu, 12 Des 2021, 00:00 | Venezia | 1 – 1 | Juventus |
| Minggu, 12 Des 2021, 02:45 | Udinese | 1 – 1 | Milan |
| Minggu, 12 Des 2021, 18:30 | Torino | 2 – 1 | Bologna |
| Minggu, 12 Des 2021, 21:00 | Hellas Verona | 1 – 2 | Atalanta |
| Senin, 13 Des 2021, 00:00 | Napoli | 0 – 1 | Empoli |
| Senin, 13 Des 2021, 00:00 | Sassuolo | 2 – 1 | Lazio |
| Senin, 13 Des 2021, 02:45 | Internazionale | 4 – 0 | Cagliari |
| Selasa, 14 Des 2021, 02:45 | Roma | 2 – 0 | Spezia |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 18 Des 2021, 00:30 | Lazio | 3 – 1 | Genoa |
| Sabtu, 18 Des 2021, 02:45 | Salernitana | 0 – 5 | Internazionale |
| Sabtu, 18 Des 2021, 21:00 | Atalanta | 1 – 4 | Roma |
| Minggu, 19 Des 2021, 00:00 | Bologna | 0 – 2 | Juventus |
| Minggu, 19 Des 2021, 02:45 | Cagliari | 0 – 4 | Udinese |
| Minggu, 19 Des 2021, 18:30 | Fiorentina | 2 – 2 | Sassuolo |
| Minggu, 19 Des 2021, 21:00 | Spezia | 1 – 1 | Empoli |
| Senin, 20 Des 2021, 00:00 | Sampdoria | 1 – 1 | Venezia |
| Senin, 20 Des 2021, 00:00 | Torino | 1 – 0 | Hellas Verona |
| Senin, 20 Des 2021, 02:45 | Milan | 0 – 1 | Napoli |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Rabu, 22 Des 2021, 02:45 | Genoa | 0 – 0 | Atalanta |
| Rabu, 22 Des 2021, 02:45 | Juventus | 2 – 0 | Cagliari |
| Rabu, 22 Des 2021, 22:30 | Sassuolo | 0 – 3 | Bologna |
| Rabu, 22 Des 2021, 22:30 | Venezia | 1 – 3 | Lazio |
| Kamis, 23 Des 2021, 00:30 | Roma | 1 – 1 | Sampdoria |
| Kamis, 23 Des 2021, 00:30 | Internazionale | 1 – 0 | Torino |
| Kamis, 23 Des 2021, 00:30 | Hellas Verona | 1 – 1 | Fiorentina |
| Kamis, 23 Des 2021, 02:45 | Empoli | 2 – 4 | Milan |
| Kamis, 23 Des 2021, 02:45 | Napoli | 0 – 1 | Spezia |
| Rabu, 20 Apr 2022, 00:00 | Udinese | 0 – 1 | Salernitana |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Kamis, 6 Jan 2022, 18:30 | Sampdoria | 1 – 2 | Cagliari |
| Kamis, 6 Jan 2022, 20:30 | Lazio | 3 – 3 | Empoli |
| Kamis, 6 Jan 2022, 20:30 | Spezia | 1 – 2 | Hellas Verona |
| Kamis, 6 Jan 2022, 22:30 | Sassuolo | 1 – 1 | Genoa |
| Jumat, 7 Jan 2022, 02:45 | Milan | 3 – 1 | Roma |
| Jumat, 7 Jan 2022, 02:45 | Juventus | 1 – 1 | Napoli |
| Rabu, 27 Apr 2022, 23:00 | Fiorentina | 0 – 4 | Udinese |
| Kamis, 28 Apr 2022, 01:15 | Atalanta | 4 – 4 | Torino |
| Kamis, 28 Apr 2022, 01:15 | Bologna | 2 – 1 | Internazionale |
| Kamis, 5 Mei 2022, 23:00 | Salernitana | 2 – 1 | Venezia |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Minggu, 9 Jan 2022, 18:30 | Empoli | 1 – 5 | Sassuolo |
| Minggu, 9 Jan 2022, 18:30 | Venezia | 0 – 3 | Milan |
| Minggu, 9 Jan 2022, 20:30 | Torino | 4 – 0 | Fiorentina |
| Minggu, 9 Jan 2022, 22:30 | Napoli | 1 – 0 | Sampdoria |
| Minggu, 9 Jan 2022, 22:30 | Udinese | 2 – 6 | Atalanta |
| Senin, 10 Jan 2022, 00:30 | Roma | 3 – 4 | Juventus |
| Senin, 10 Jan 2022, 00:30 | Genoa | 0 – 1 | Spezia |
| Senin, 10 Jan 2022, 02:45 | Internazionale | 2 – 1 | Lazio |
| Senin, 10 Jan 2022, 02:45 | Hellas Verona | 1 – 2 | Salernitana |
| Rabu, 12 Jan 2022, 02:45 | Cagliari | 2 – 1 | Bologna |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 15 Jan 2022, 21:00 | Sampdoria | 1 – 2 | Torino |
| Minggu, 16 Jan 2022, 00:00 | Salernitana | 0 – 3 | Lazio |
| Minggu, 16 Jan 2022, 02:45 | Juventus | 2 – 0 | Udinese |
| Minggu, 16 Jan 2022, 18:30 | Sassuolo | 2 – 4 | Hellas Verona |
| Minggu, 16 Jan 2022, 21:00 | Bologna | 0 – 2 | Napoli |
| Minggu, 16 Jan 2022, 21:00 | Venezia | 1 – 1 | Empoli |
| Senin, 17 Jan 2022, 00:00 | Roma | 1 – 0 | Cagliari |
| Senin, 17 Jan 2022, 02:45 | Atalanta | 0 – 0 | Internazionale |
| Selasa, 18 Jan 2022, 00:30 | Milan | 1 – 2 | Spezia |
| Selasa, 18 Jan 2022, 02:45 | Fiorentina | 6 – 0 | Genoa |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 22 Jan 2022, 02:45 | Hellas Verona | 2 – 1 | Bologna |
| Sabtu, 22 Jan 2022, 21:00 | Genoa | 0 – 0 | Udinese |
| Minggu, 23 Jan 2022, 00:00 | Internazionale | 2 – 1 | Venezia |
| Minggu, 23 Jan 2022, 02:45 | Lazio | 0 – 0 | Atalanta |
| Minggu, 23 Jan 2022, 18:30 | Cagliari | 1 – 1 | Fiorentina |
| Minggu, 23 Jan 2022, 21:00 | Napoli | 4 – 1 | Salernitana |
| Minggu, 23 Jan 2022, 21:00 | Spezia | 1 – 0 | Sampdoria |
| Minggu, 23 Jan 2022, 21:00 | Torino | 1 – 1 | Sassuolo |
| Senin, 24 Jan 2022, 00:00 | Empoli | 2 – 4 | Roma |
| Senin, 24 Jan 2022, 02:45 | Milan | 0 – 0 | Juventus |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 5 Feb 2022, 21:00 | Roma | 0 – 0 | Genoa |
| Minggu, 6 Feb 2022, 00:00 | Internazionale | 1 – 2 | Milan |
| Minggu, 6 Feb 2022, 02:45 | Fiorentina | 0 – 3 | Lazio |
| Minggu, 6 Feb 2022, 18:30 | Atalanta | 1 – 2 | Cagliari |
| Minggu, 6 Feb 2022, 21:00 | Bologna | 0 – 0 | Empoli |
| Minggu, 6 Feb 2022, 21:00 | Sampdoria | 4 – 0 | Sassuolo |
| Minggu, 6 Feb 2022, 21:00 | Venezia | 0 – 2 | Napoli |
| Senin, 7 Feb 2022, 00:00 | Udinese | 2 – 0 | Torino |
| Senin, 7 Feb 2022, 02:45 | Juventus | 2 – 0 | Hellas Verona |
| Selasa, 8 Feb 2022, 02:45 | Salernitana | 2 – 2 | Spezia |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 12 Feb 2022, 21:00 | Lazio | 3 – 0 | Bologna |
| Minggu, 13 Feb 2022, 00:00 | Napoli | 1 – 1 | Internazionale |
| Minggu, 13 Feb 2022, 02:45 | Torino | 1 – 2 | Venezia |
| Minggu, 13 Feb 2022, 18:30 | Milan | 1 – 0 | Sampdoria |
| Minggu, 13 Feb 2022, 21:00 | Empoli | 1 – 1 | Cagliari |
| Minggu, 13 Feb 2022, 21:00 | Genoa | 1 – 1 | Salernitana |
| Minggu, 13 Feb 2022, 21:00 | Hellas Verona | 4 – 0 | Udinese |
| Senin, 14 Feb 2022, 00:00 | Sassuolo | 2 – 2 | Roma |
| Senin, 14 Feb 2022, 02:45 | Atalanta | 1 – 1 | Juventus |
| Selasa, 15 Feb 2022, 02:45 | Spezia | 1 – 2 | Fiorentina |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 19 Feb 2022, 02:45 | Juventus | 1 – 1 | Torino |
| Sabtu, 19 Feb 2022, 21:00 | Sampdoria | 2 – 0 | Empoli |
| Minggu, 20 Feb 2022, 00:00 | Roma | 2 – 2 | Hellas Verona |
| Minggu, 20 Feb 2022, 02:45 | Salernitana | 2 – 2 | Milan |
| Minggu, 20 Feb 2022, 18:30 | Fiorentina | 1 – 0 | Atalanta |
| Minggu, 20 Feb 2022, 21:00 | Venezia | 1 – 1 | Genoa |
| Senin, 21 Feb 2022, 00:00 | Internazionale | 0 – 2 | Sassuolo |
| Senin, 21 Feb 2022, 02:45 | Udinese | 1 – 1 | Lazio |
| Selasa, 22 Feb 2022, 01:00 | Cagliari | 1 – 1 | Napoli |
| Selasa, 22 Feb 2022, 03:00 | Bologna | 2 – 1 | Spezia |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 26 Feb 2022, 00:50 | Milan | 1 – 1 | Udinese |
| Sabtu, 26 Feb 2022, 03:05 | Genoa | 0 – 0 | Internazionale |
| Sabtu, 26 Feb 2022, 21:05 | Salernitana | 1 – 1 | Bologna |
| Minggu, 27 Feb 2022, 00:05 | Empoli | 2 – 3 | Juventus |
| Minggu, 27 Feb 2022, 02:50 | Sassuolo | 2 – 1 | Fiorentina |
| Minggu, 27 Feb 2022, 18:35 | Torino | 1 – 2 | Cagliari |
| Minggu, 27 Feb 2022, 21:05 | Hellas Verona | 3 – 1 | Venezia |
| Senin, 28 Feb 2022, 00:05 | Spezia | 0 – 1 | Roma |
| Senin, 28 Feb 2022, 02:50 | Lazio | 1 – 2 | Napoli |
| Selasa, 1 Mar 2022, 02:50 | Atalanta | 4 – 0 | Sampdoria |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 5 Mar 2022, 02:45 | Internazionale | 5 – 0 | Salernitana |
| Sabtu, 5 Mar 2022, 21:00 | Udinese | 2 – 1 | Sampdoria |
| Minggu, 6 Mar 2022, 00:00 | Roma | 1 – 0 | Atalanta |
| Minggu, 6 Mar 2022, 02:45 | Cagliari | 0 – 3 | Lazio |
| Minggu, 6 Mar 2022, 18:30 | Genoa | 0 – 0 | Empoli |
| Minggu, 6 Mar 2022, 21:00 | Bologna | 0 – 0 | Torino |
| Minggu, 6 Mar 2022, 21:00 | Fiorentina | 1 – 1 | Hellas Verona |
| Minggu, 6 Mar 2022, 21:00 | Venezia | 1 – 4 | Sassuolo |
| Senin, 7 Mar 2022, 00:00 | Juventus | 1 – 0 | Spezia |
| Senin, 7 Mar 2022, 02:45 | Napoli | 0 – 1 | Milan |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 12 Mar 2022, 21:00 | Salernitana | 2 – 2 | Sassuolo |
| Sabtu, 12 Mar 2022, 21:00 | Spezia | 2 – 0 | Cagliari |
| Minggu, 13 Mar 2022, 00:00 | Sampdoria | 1 – 3 | Juventus |
| Minggu, 13 Mar 2022, 02:45 | Milan | 1 – 0 | Empoli |
| Minggu, 13 Mar 2022, 18:30 | Fiorentina | 1 – 0 | Bologna |
| Minggu, 13 Mar 2022, 21:00 | Hellas Verona | 1 – 2 | Napoli |
| Senin, 14 Mar 2022, 00:00 | Atalanta | 0 – 0 | Genoa |
| Senin, 14 Mar 2022, 00:00 | Udinese | 1 – 1 | Roma |
| Senin, 14 Mar 2022, 02:45 | Torino | 1 – 1 | Internazionale |
| Selasa, 15 Mar 2022, 02:45 | Lazio | 1 – 0 | Venezia |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 19 Mar 2022, 00:45 | Sassuolo | 4 – 1 | Spezia |
| Sabtu, 19 Mar 2022, 03:00 | Genoa | 1 – 0 | Torino |
| Sabtu, 19 Mar 2022, 21:00 | Napoli | 2 – 1 | Udinese |
| Minggu, 20 Mar 2022, 00:00 | Internazionale | 1 – 1 | Fiorentina |
| Minggu, 20 Mar 2022, 02:45 | Cagliari | 0 – 1 | Milan |
| Minggu, 20 Mar 2022, 18:30 | Venezia | 0 – 2 | Sampdoria |
| Minggu, 20 Mar 2022, 21:00 | Empoli | 1 – 1 | Hellas Verona |
| Minggu, 20 Mar 2022, 21:00 | Juventus | 2 – 0 | Salernitana |
| Senin, 21 Mar 2022, 00:00 | Roma | 3 – 0 | Lazio |
| Senin, 21 Mar 2022, 02:45 | Bologna | 0 – 1 | Atalanta |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 2 Apr 2022, 20:00 | Spezia | 1 – 0 | Venezia |
| Sabtu, 2 Apr 2022, 23:00 | Lazio | 2 – 1 | Sassuolo |
| Minggu, 3 Apr 2022, 01:45 | Salernitana | 0 – 1 | Torino |
| Minggu, 3 Apr 2022, 17:30 | Fiorentina | 1 – 0 | Empoli |
| Minggu, 3 Apr 2022, 20:00 | Atalanta | 1 – 3 | Napoli |
| Minggu, 3 Apr 2022, 20:00 | Udinese | 5 – 1 | Cagliari |
| Minggu, 3 Apr 2022, 23:00 | Sampdoria | 0 – 1 | Roma |
| Senin, 4 Apr 2022, 01:45 | Juventus | 0 – 1 | Internazionale |
| Senin, 4 Apr 2022, 23:30 | Hellas Verona | 1 – 0 | Genoa |
| Selasa, 5 Apr 2022, 01:45 | Milan | 0 – 0 | Bologna |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 9 Apr 2022, 20:00 | Empoli | 0 – 0 | Spezia |
| Sabtu, 9 Apr 2022, 23:00 | Internazionale | 2 – 0 | Hellas Verona |
| Minggu, 10 Apr 2022, 01:45 | Cagliari | 1 – 2 | Juventus |
| Minggu, 10 Apr 2022, 17:30 | Genoa | 1 – 4 | Lazio |
| Minggu, 10 Apr 2022, 20:00 | Napoli | 2 – 3 | Fiorentina |
| Minggu, 10 Apr 2022, 20:00 | Sassuolo | 2 – 1 | Atalanta |
| Minggu, 10 Apr 2022, 20:00 | Venezia | 1 – 2 | Udinese |
| Minggu, 10 Apr 2022, 23:00 | Roma | 2 – 1 | Salernitana |
| Senin, 11 Apr 2022, 01:45 | Torino | 0 – 0 | Milan |
| Selasa, 12 Apr 2022, 01:45 | Bologna | 2 – 0 | Sampdoria |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 16 Apr 2022, 00:00 | Spezia | 1 – 3 | Internazionale |
| Sabtu, 16 Apr 2022, 02:00 | Milan | 2 – 0 | Genoa |
| Sabtu, 16 Apr 2022, 17:30 | Cagliari | 1 – 0 | Sassuolo |
| Sabtu, 16 Apr 2022, 19:30 | Sampdoria | 1 – 2 | Salernitana |
| Sabtu, 16 Apr 2022, 19:30 | Udinese | 4 – 1 | Empoli |
| Sabtu, 16 Apr 2022, 21:30 | Fiorentina | 1 – 0 | Venezia |
| Sabtu, 16 Apr 2022, 23:30 | Juventus | 1 – 1 | Bologna |
| Minggu, 17 Apr 2022, 01:45 | Lazio | 1 – 1 | Torino |
| Selasa, 19 Apr 2022, 00:00 | Napoli | 1 – 1 | Roma |
| Selasa, 19 Apr 2022, 02:00 | Atalanta | 1 – 2 | Hellas Verona |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 23 Apr 2022, 20:00 | Torino | 2 – 1 | Spezia |
| Sabtu, 23 Apr 2022, 20:00 | Venezia | 1 – 3 | Atalanta |
| Sabtu, 23 Apr 2022, 23:00 | Internazionale | 3 – 1 | Roma |
| Minggu, 24 Apr 2022, 01:45 | Hellas Verona | 1 – 1 | Sampdoria |
| Minggu, 24 Apr 2022, 17:30 | Salernitana | 2 – 1 | Fiorentina |
| Minggu, 24 Apr 2022, 20:00 | Bologna | 2 – 2 | Udinese |
| Minggu, 24 Apr 2022, 20:00 | Empoli | 3 – 2 | Napoli |
| Minggu, 24 Apr 2022, 23:00 | Genoa | 1 – 0 | Cagliari |
| Senin, 25 Apr 2022, 01:45 | Lazio | 1 – 2 | Milan |
| Selasa, 26 Apr 2022, 01:45 | Sassuolo | 1 – 2 | Juventus |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 30 Apr 2022, 20:00 | Cagliari | 1 – 2 | Hellas Verona |
| Sabtu, 30 Apr 2022, 20:00 | Napoli | 6 – 1 | Sassuolo |
| Sabtu, 30 Apr 2022, 23:00 | Sampdoria | 1 – 0 | Genoa |
| Minggu, 1 Mei 2022, 01:45 | Spezia | 3 – 4 | Lazio |
| Minggu, 1 Mei 2022, 17:30 | Juventus | 2 – 1 | Venezia |
| Minggu, 1 Mei 2022, 20:00 | Milan | 1 – 0 | Fiorentina |
| Minggu, 1 Mei 2022, 20:00 | Empoli | 1 – 3 | Torino |
| Minggu, 1 Mei 2022, 23:00 | Udinese | 1 – 2 | Internazionale |
| Senin, 2 Mei 2022, 01:45 | Roma | 0 – 0 | Bologna |
| Selasa, 3 Mei 2022, 01:45 | Atalanta | 1 – 1 | Salernitana |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Jumat, 6 Mei 2022, 23:45 | Internazionale | 4 – 2 | Empoli |
| Sabtu, 7 Mei 2022, 02:00 | Genoa | 2 – 1 | Juventus |
| Sabtu, 7 Mei 2022, 20:00 | Torino | 0 – 1 | Napoli |
| Sabtu, 7 Mei 2022, 23:00 | Sassuolo | 1 – 1 | Udinese |
| Minggu, 8 Mei 2022, 01:45 | Lazio | 2 – 0 | Sampdoria |
| Minggu, 8 Mei 2022, 17:30 | Spezia | 1 – 3 | Atalanta |
| Minggu, 8 Mei 2022, 20:00 | Venezia | 4 – 3 | Bologna |
| Minggu, 8 Mei 2022, 23:00 | Salernitana | 1 – 1 | Cagliari |
| Senin, 9 Mei 2022, 01:45 | Hellas Verona | 1 – 3 | Milan |
| Selasa, 10 Mei 2022, 01:45 | Fiorentina | 2 – 0 | Roma |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 14 Mei 2022, 20:00 | Empoli | 1 – 1 | Salernitana |
| Sabtu, 14 Mei 2022, 23:00 | Udinese | 2 – 3 | Spezia |
| Sabtu, 14 Mei 2022, 23:00 | Hellas Verona | 0 – 1 | Torino |
| Minggu, 15 Mei 2022, 01:45 | Roma | 1 – 1 | Venezia |
| Minggu, 15 Mei 2022, 17:30 | Bologna | 1 – 3 | Sassuolo |
| Minggu, 15 Mei 2022, 20:00 | Napoli | 3 – 0 | Genoa |
| Minggu, 15 Mei 2022, 23:00 | Milan | 2 – 0 | Atalanta |
| Senin, 16 Mei 2022, 01:45 | Cagliari | 1 – 3 | Internazionale |
| Senin, 16 Mei 2022, 23:30 | Sampdoria | 4 – 1 | Fiorentina |
| Selasa, 17 Mei 2022, 01:45 | Juventus | 2 – 2 | Lazio |
| Waktu (WIB) | Home | Skor | Away |
|---|
| Sabtu, 21 Mei 2022, 01:45 | Torino | 0 – 3 | Roma |
| Sabtu, 21 Mei 2022, 22:15 | Genoa | 0 – 1 | Bologna |
| Minggu, 22 Mei 2022, 01:45 | Atalanta | 0 – 1 | Empoli |
| Minggu, 22 Mei 2022, 01:45 | Fiorentina | 2 – 0 | Juventus |
| Minggu, 22 Mei 2022, 01:45 | Lazio | 3 – 3 | Hellas Verona |
| Minggu, 22 Mei 2022, 17:30 | Spezia | 0 – 3 | Napoli |
| Minggu, 22 Mei 2022, 23:00 | Internazionale | 3 – 0 | Sampdoria |
| Minggu, 22 Mei 2022, 23:00 | Sassuolo | 0 – 3 | Milan |
| Senin, 23 Mei 2022, 02:00 | Salernitana | 0 – 4 | Udinese |
| Senin, 23 Mei 2022, 02:00 | Venezia | 0 – 0 | Cagliari |
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